CLUSTAL AR11_XENLA/62-162 LLEATEEFELRYQRAFSDLTSQLHITQD.....TAQQSFQQVMGELFRDG....-TNWGR AR1_XENLA/81-181 MRAAGDEFEERFRQAFSEISTQIHVTPG.....TAYARFAEVAGSLFQGG....-VNWGR B2L10_HUMAN/71-155 ----------------------------.....--------MADSVLSDSp...GPTWGR B2L10_MOUSE/42-153 LRSVTRQIQQEHQEFFSSFCESRGNR--.....-LELVKQMADKLLSKDQ....DFSWSQ B2L13_HUMAN/104-202 LAHLGEKVSQELKEPLHKALQMLLSQP-.....VTYQAFRECTLETTVHA....-SGWNK B2L13_MOUSE/101-199 LAHLGERVSQDLKEPLQKALQTILSQP-.....VTYEAYRECTVETAVHA....-SGWNK B2L14_HUMAN/270-317 ----------------------------.....-----------------....------ B2L14_MOUSE/271-318 ----------------------------.....-----------------....------ B2L14_RAT/269-316 ----------------------------.....-----------------....------ BAK2_HUMAN/78-179 LAIIGDDINRRYDSEFQTMLQHLQPTAE.....NAYEYFTKIASSLFESG....-INWGR BAK_HUMAN/78-179 LAIIGDDINRRYDSEFQTMLQHLQPTAE.....NAYEYFTKIATSLFESG....-INWGR BAK_MOUSE/75-176 LALIGDDINRRYDTEFQNLLEQLQPTAG.....NAYELFTKIASSLFKSG....-ISWGR BAXA_BOVIN/63-160 LKRIGDELDSNM--ELQRMIAAVDTD--.....SPREVFFRVAAEMFSDG....NFNWGR BAXA_HUMAN/63-160 LKRIGDELDSNM--ELQRMIAAVDTD--.....SPREVFFRVAADMFSDG....NFNWGR BAXA_MOUSE/63-160 LRRIGDELDSNM--ELQRMIADVDTD--.....SPREVFFRVAADMFADG....NFNWGR BAXA_RAT/63-160 LRRIGDELDSNM--ELQRMIADVDTD--.....SPREVFFRVAADMFADG....NFNWGR BAXB_HUMAN/63-160 LKRIGDELDSNM--ELQRMIAAVDTD--.....SPREVFFRVAADMFSDG....NFNWGR BAXD_HUMAN/27-111 ---------------LQGMIAAVDTD--.....SPREVFFRVAADMFSDG....NFNWGR BCL2_BOVIN/87-187 LRQAGDDFSRRYRRDFAEMSSQLHLTPF.....TARERFATVVEELFRDG....-VNWGR BCL2_CHICK/91-191 LRQAGDEFSRRYQRDFAQMSGQLHLTPF.....TAHGRFVAVVEELFRDG....-VNWGR BCL2_CRILO/94-194 LRRAGDDFSRRYRRDFAEMSSQLHLTPF.....TARGRFATVVEELFRDG....-VNWGR BCL2_HUMAN/97-197 LRQAGDDFSRRYRRDFAEMSSQLHLTPF.....TARGRFATVVEELFRDG....-VNWGR BCL2_MOUSE/94-194 LRRAGDDFSRRYRRDFAEMSSQLHLTPF.....TARGRFATVVEELFRDG....-VNWGR BCL2_RAT/94-194 LRRAGDDFSRRYRRDFAEMSSQLHLTPF.....TARGRFATVVEELFRDG....-VNWGR BCLW_HUMAN/46-146 MRAAGDEFETRFRRTFSDLAAQLHVTPG.....SAQQRFTQVSDELFQGG....-PNWGR BCLW_MOUSE/46-146 MRAAGDEFETRFRRTFSDLAAQLHVTPG.....SAQQRFTQVSDELFQGG....-PNWGR BCLX_CHICK/86-186 LRDAGDEFELRYRRAFSDLTSQLHITPG.....TAYQSFEQVVNELFHDG....-VNWGR BCLX_HUMAN/90-190 LREAGDEFELRYRRAFSDLTSQLHITPG.....TAYQSFEQVVNELFRDG....-VNWGR BCLX_MOUSE/90-190 LREAGDEFELRYRRAFSDLTSQLHITPG.....TAYQSFEQVVNELFRDG....-VNWGR BCLX_PIG/90-190 LREAGDEFELRYRRAFSDLTSQLHITPG.....TAYQSFEQVLNELFRDG....-VNWGR BCLX_RAT/90-190 LREAGDEFELRYRRAFSDLTSQLHITPG.....TAYQSFEQVVNELFRDG....-VNWGR BFL1_HUMAN/37-142 LQNVAFSVQKEVEKNLKSCLDNVNVVSVd....TARTLFNQVMEKEFEDG....IINWGR BFL1_MOUSE/37-142 LQRVAFSVQKEVEKNLKSYLDDFHVESId....TARIIFNQVMEKEFEDG....IINWGR BOK_BRARE/71-174 LLKLGDELECMRPYVYRNIAKQLNISVSve..aVVSDAFLSVATEVIAMG....-ITWGK BOK_CHICK/71-174 LLRLGDELEYIRPNVYRNIARQLNISLHse..tVVTDAFLAVAAQIFTAG....-ITWGK BOK_HUMAN/70-173 LLRLGDELEMIRPSVYRNVARQLHISLQse..pVVTDAFLAVAGHIFSAG....-ITWGK BOK_MOUSE/71-174 LLRLGDELEQIRPSVYRNVARQLHIPLQse..pVVTDAFLAVAGHIFSAG....-ITWGK BOK_RAT/71-174 LLRLGDELEQIRPSVYRNVARQLHIPLQse..pVVTDAFLAVAGHIFSAG....-ITWGK CED9_CAEBR/111-218 MRSLGTIFEKRHMEMFENFSEQLLAVPK.....ISFSLYQEVVQTVGNSSntpcPMSYGR CED9_CAEEL/116-223 MRVMGTIFEKKHAENFETFCEQLLAVPR.....ISFSLYQDVVRTVGNAQtdqcPMSYGR E1BS_ADE02/36-131 QAKLVCRIKEDYKWEFEELLKSCGELFD.....SLNLGHQALFQEKVIKTl..dFSTPGR E1BS_ADE04/36-130 LAKLVYRAKQDYREQFEDILRECPSLFD.....ALNLGHQSHFNQRISRAl..dFTTPGR E1BS_ADE05/36-131 QAKLVCRIKEDYKWEFEELLKSCGELFD.....SLNLGHQALFQEKVIKTl..dFSTPGR E1BS_ADE07/36-130 LARLVFRIKQDYREEFEKLLDDIPGLFE.....ALNLGHQAHFKEKVLSVl..dFSTPGR E1BS_ADE12/36-130 LSKVVNRVKEDYREEFENILADCPGLLA.....SLDLCYHLVFQEKVVRSl..dFSSVGR E1BS_ADE40/36-130 LTNVIYRAKEEYSSRFADLLSHNPGIFA.....SLNLGHHSFFQEIVIRNl..dFSSPGR E1BS_ADE41/36-130 LTNVIYRAKEDYSSRFAELLSFNPGIFA.....SLNLGHHSFFQEIVIKNl..dFSSPGR E1BS_ADEC2/34-152 LADVVGNIVVQEEGRFWQILPENHAFWG.....LLRRGFTVASFTEIITAaqleNERLSR E1BS_ADECC/35-128 LADVVGNIVEREEGRFWEIVPETHTLWA.....LFRGGFTVAPFTEILTSl..qLENRGR E1BS_ADECG/35-128 LADVVGNIVEREEGRFWEIVPETHTLWA.....VFRGGFTVAPFTEILTSl..qLENRGR E1BS_ADECR/35-128 LADVVGNIVEREEGRFWEIVPETHTLWA.....LFRGGFTVAPFTEILTSl..qLENRGR E1BS_ADECT/35-151 LADVVGNIVEQEEGRFWQILPENHAFWG.....LLRRGFTVASFTEIITAa..qLENRGR E1BS_ADES7/36-130 LSRLVRQVKLEYEKDFERILDQCPGVFE.....SLELGYHKVFEEKIVKEl..dFSSPGR EAR_ASFB7/32-136 LSPYQQQIKKILTYYDECLNKQVTITFSltsvqEIKTQFTGVVTELFKDL....-INWGR EAR_ASFE4/32-136 LSPYQQQIKKILTYYDECLNKQVTITFSltsvqEIKTQFTGVVTELFRDL....-INWGR EAR_ASFM2/32-136 LSPYQQQIKKILTYYDECLNKQVTITFSltnaqEIKTQFTGVVTELFKDL....-INWGR EAR_EBV/50-152 YHVLLEEIIERNSETFTETWNRFITHTE.....HVDLDFNSVFLEIFHRG....DPSLGR MCL1_HUMAN/213-314 LRRVGDGVQRNHETAFQGMLRKLDIKNE.....DDVKSLSRVMIHVFSDG....VTNWGR NR13_COTJA/35-136 LRRAAAELERRERPFFRSCAPLARAEPR.....EAAALLRKVAAQLETDG....GLNWGR V039_FOWPV/69-137 ----------------------------.....-----FNVIVTQVLEDK....-INWGR VG16_SHV21/27-123 VVRAVHSVIHQYN-KFEALMPDFSLCVH.....-DRIKFTGEAILLTTEH....TTNWGK AR11_XENLA/62-162 IVAFFSFGRALCVESANKEMTDLL..................PRIVQWMVNYLEHT.... AR1_XENLA/81-181 IVAFFVFGAALCAESVNKEMSPLL..................PRIQDWMVTYLETN.... B2L10_HUMAN/71-155 VVTLVTFAGTLLERGPLVTARWKKwgfqprlkeqegdvardcQRLVALLSSRLMGQ.... B2L10_MOUSE/42-153 LVMLLAFAGTLMNQGPYMAVKQKRdlgnrv......ivtrdcCLIVNFLYNLLMGRr... B2L13_HUMAN/104-202 ILVPLVLLRQMLLELTRRGQEPL-..................SALLQFGVTYLEDY.... B2L13_MOUSE/101-199 LLVPLVLLQHLLLELTRRGQEPL-..................RMLLQFGVMYLEEH.... B2L14_HUMAN/270-317 ------FKAALVIDVTAKLTAIDNhp...............mNRVLGFGTKYLKEN.... B2L14_MOUSE/271-318 ------FKAALAIDAIAKLTAIDNhp...............mNRMLGFGTKYLREY.... B2L14_RAT/269-316 ------FKAALAIDAIAKLTAIDNhp...............mNRMLGFGTKYLREY.... BAK2_HUMAN/78-179 VVALLGFSYRLALHIYQRGLTGFL..................GQVTRFVVDFMLHHc... BAK_HUMAN/78-179 VVALLGFGYRLALHVYQHGLTGFL..................GQVTRFVVDFMLHHc... BAK_MOUSE/75-176 VVALLGFGYRLALYVYQRGLTGFL..................GQVTCFLADIILHHy... BAXA_BOVIN/63-160 VVALFYFASKLVLKALCTKVPELI..................RTIMGWTLDFLRER.... BAXA_HUMAN/63-160 VVALFYFASKLVLKALCTKVPELI..................RTIMGWTLDFLRER.... BAXA_MOUSE/63-160 VVALFYFASKLVLKALCTKVPELI..................RTIMGWTLDFLRER.... BAXA_RAT/63-160 VVALFYFASKLVLKALCTKVPELI..................RTIMGWTLDFLRER.... BAXB_HUMAN/63-160 VVALFYFASKLVLKALCTKVPELI..................RTIMGWTLDFLRER.... BAXD_HUMAN/27-111 VVALFYFASKLVLKALCTKVPELI..................RTIMGWTLDFLRER.... BCL2_BOVIN/87-187 IVAFFEFGGVMCVESVNREMSPLV..................DSIALWMTEYLNRH.... BCL2_CHICK/91-191 IVAFFEFGGVMCVESVNREMSPLV..................DNIATWMTEYLNRH.... BCL2_CRILO/94-194 IVAFFEFGGVMCVESVNREMSPLV..................DNIALWMTEYLNRH.... BCL2_HUMAN/97-197 IVAFFEFGGVMCVESVNREMSPLV..................DNIALWMTEYLNRH.... BCL2_MOUSE/94-194 IVAFFEFGGVMCVESVNREMSPLV..................DNIALWMTEYLNRH.... BCL2_RAT/94-194 IVAFFEFGGVMCVESVNREMSPLV..................DNIALWMTEYLNRH.... BCLW_HUMAN/46-146 LVAFFVFGAALCAESVNKEMEPLV..................GQVQEWMVAYLETR.... BCLW_MOUSE/46-146 LVAFFVFGAALCAESVNKEMEPLV..................GQVQDWMVAYLETR.... BCLX_CHICK/86-186 IVAFFSFGGALCVESVDKEMRVLV..................GRIVSWMTTYLTDH.... BCLX_HUMAN/90-190 IVAFFSFGGALCVESVDKEMQVLV..................SRIAAWMATYLNDH.... BCLX_MOUSE/90-190 IVAFFSFGGALCVESVDKEMQVLV..................SRIASWMATYLNDH.... BCLX_PIG/90-190 IVAFFSFGGALCVESVDKEMQVLV..................SRIATWMATYLNDH.... BCLX_RAT/90-190 IVAFFSFGGALCVESVDKEMQVLV..................SRIASWMATYLNDH.... BFL1_HUMAN/37-142 IVTIFAFEGILIKKLLRQQIAPDVdt...............yKEISYFVAEFIMNN.... BFL1_MOUSE/37-142 IVTIFAFGGVLLKKLPQEQIALDVca...............yKQVSSFVAEFIMNN.... BOK_BRARE/71-174 VVAIYAVAAGLAVDCVRLGHPVMV..................HTIVDSLGEFVRRS.... BOK_CHICK/71-174 VVSLYAVAAGLAVDCVRHAQPAMV..................HTIVDCLGEFVRKT.... BOK_HUMAN/70-173 VVSLYAVAAGLAVDCVRQAQPAMV..................HALVDCLGEFVRKT.... BOK_MOUSE/71-174 VVSLYSVAAGLAVDCVRQAQPAMV..................HALVDCLGEFVRKT.... BOK_RAT/71-174 VVSLYSVAAGLAVDCVRQAQPAMV..................HALVDCLGEFVRKT.... CED9_CAEBR/111-218 LIGLISFGGMVAAKMMESAELQGQv.................RNLLMYTSLFIKTRi... CED9_CAEEL/116-223 LIGLISFGGFVAAKMMESVELQGQv.................RNLFVYTSLFIKTRi... E1BS_ADE02/36-131 AAAAVAFLSFIKDKWSEETH----..................-LSGGYLLDFLAMHl... E1BS_ADE04/36-130 TTAAVAFFAFIFDKWSQETH----..................-FSRDYQLDFLAVAl... E1BS_ADE05/36-131 AAAAVAFLSFIKDKWSEETH----..................-LSGGYLLDFLAMHl... E1BS_ADE07/36-130 TAAAVAFLTFILDKWIRQTH----..................-FSKGYVLDFIAAAl... E1BS_ADE12/36-130 TVASIAFLATILDKWSEKSH----..................-LSWDYMLDYMSMQl... E1BS_ADE40/36-130 TVSGLAFICFILDQWSAQTH----..................-LSQGYTLDYMAMAl... E1BS_ADE41/36-130 TVSGLAFICFILDQWSAQTH----..................-LSEGYTLDYMTMAl... E1BS_ADEC2/34-152 QLAFLAFISFLLRNWPSDSLVPEAdrldlvc.....apawsrMQIWTQTARLINDL.... E1BS_ADECC/35-128 QLAFLAFLSFLLRNWPSDSV----..................-VSEDARLDLVCAPawsr E1BS_ADECG/35-128 QLAFLAFLSFLLRNWPSDSV----..................-VSEDARLDLVCAPawsr E1BS_ADECR/35-128 QLAFLAFLSFLLRNWPSDSV----..................-VSEDARLDLVCAPawsr E1BS_ADECT/35-151 QLAFLAFISFLLRNWPSDSVVPEAdrldlvc.....apawsrMQIWSQTARLINDL.... E1BS_ADES7/36-130 AVAAVAFASYLLDRWNTRTH----..................-LSPGYQMDYISLNl... EAR_ASFB7/32-136 ICGFIVFSAKMAKYCKDANNHLE-..................STVITTAYNFMKHN.... EAR_ASFE4/32-136 ICGFIVFSARMAKYCKDANNHLE-..................STVITTAYNFMKHN.... EAR_ASFM2/32-136 ICGFIVFSARMAKYCKDANNHLE-..................STVITTAYNFMKHN.... EAR_EBV/50-152 ALAWMAWCMHACRTLCCNQSTPYY..................-VVDLSVRGMLEASe..g MCL1_HUMAN/213-314 IVTLISFGAFVAKHLKTINQESCI..................EPLAESITDVLVRT.... NR13_COTJA/35-136 LLALVVFAGTLAAALAESACEEGP..................SRLAAALTAYLAEE.... V039_FOWPV/69-137 IITIIAFCAYYSKKVKQDTSPQYYd.................GIISEAITDAILSK.... VG16_SHV21/27-123 VVAMLSFSAAVLQTIDEEYK----..................CVATSMLSSYISRSv... AR11_XENLA/62-162 LQPWMQENGGWEA AR1_XENLA/81-181 LRDWIQSNGGWNG B2L10_HUMAN/71-155 HRAWLQAQGGWDG B2L10_MOUSE/42-153 HRARLEALGGWDG B2L13_HUMAN/104-202 SAEYIIQQGGWGT B2L13_MOUSE/101-199 AAEFIIQQGGWGS B2L14_HUMAN/270-317 FSPWIQQHGGWEK B2L14_MOUSE/271-318 FSPWVQQNGGWEK B2L14_RAT/269-316 FSPWVQQNGGWEK BAK2_HUMAN/78-179 IARWIAQRGGWVA BAK_HUMAN/78-179 IARWIAQRGGWVA BAK_MOUSE/75-176 IARWIAQRGGWVA BAXA_BOVIN/63-160 LLGWIQDQGGWDG BAXA_HUMAN/63-160 LLGWIQDQGGWDG BAXA_MOUSE/63-160 LLVWIQDQGGWEG BAXA_RAT/63-160 LLVWIQDQGGWDG BAXB_HUMAN/63-160 LLGWIQDQGGWVR BAXD_HUMAN/27-111 LLGWIQDQGGWDG BCL2_BOVIN/87-187 LHTWIQDNGGWDA BCL2_CHICK/91-191 LHNWIQDNGGWDA BCL2_CRILO/94-194 LHTWIQDNGGWDA BCL2_HUMAN/97-197 LHTWIQDNGGWDA BCL2_MOUSE/94-194 LHTWIQDNGGWDA BCL2_RAT/94-194 LHTWIQDNGGWDA BCLW_HUMAN/46-146 LADWIHSSGGWAE BCLW_MOUSE/46-146 LADWIHSSGGWAE BCLX_CHICK/86-186 LDPWIQENGGWER BCLX_HUMAN/90-190 LEPWIQENGGWDT BCLX_MOUSE/90-190 LEPWIQENGGWDT BCLX_PIG/90-190 LEPWIQENGGWDT BCLX_RAT/90-190 LEPWIQENGGWDT BFL1_HUMAN/37-142 TGEWIRQNGGWEN BFL1_MOUSE/37-142 TGEWIRQNGGWED BOK_BRARE/71-174 LVPWLKKRGGWVD BOK_CHICK/71-174 LVTWLKRRGGWAD BOK_HUMAN/70-173 LATWLRRRGGWTD BOK_MOUSE/71-174 LATWLRRRGGWTD BOK_RAT/71-174 LATWLRRRGGWTD CED9_CAEBR/111-218 RQSWKEHNRSWAD CED9_CAEEL/116-223 RNNWKEHNRSWDD E1BS_ADE02/36-131 WRAVVRHKN---- E1BS_ADE04/36-130 WRTWKCQR----- E1BS_ADE05/36-131 WRAVVRHKN---- E1BS_ADE07/36-130 WRTWKARR----- E1BS_ADE12/36-130 WRAWLKRR----- E1BS_ADE40/36-130 WRTLLRRK----- E1BS_ADE41/36-130 WRTLLRRK----- E1BS_ADEC2/34-152 QDSVLEEQGSAEE E1BS_ADECC/35-128 IQIW--------- E1BS_ADECG/35-128 IQIW--------- E1BS_ADECR/35-128 IQIW--------- E1BS_ADECT/35-151 QDSVLEEQGSAEE E1BS_ADES7/36-130 WKFWLRRR----- EAR_ASFB7/32-136 LLPWMISHGGQEE EAR_ASFE4/32-136 LLPWMISHGGQEE EAR_ASFM2/32-136 LLPWMISHGGQEE EAR_EBV/50-152 LDGWIHQQGGWST MCL1_HUMAN/213-314 KRDWLVKQRGWDG NR13_COTJA/35-136 QGEWMEEHGGWDG V039_FOWPV/69-137 YRSWFIDQDYWNG VG16_SHV21/27-123 GANWFIENGGEKS